{"product_id":"snow-mushroom-polysaccharides-hyaluronic-acid-substitute-90","title":"Snow Mushroom Polysaccharides • Hyaluronic Acid Substitute 90%","description":"\u003cp\u003eSnow Mushroom Polysaccharides are a water-soluble polymer, the molecular structure backbone of which is composed of α-(1-3)-glycosidic bone-linked mannosan, with branched chains consisting of glucuronic acids, xyloses, and fucoses. Its active center is a common structural part: α-(1-3)-mannan.\u003c\/p\u003e\n\u003cp\u003eTremella polysaccharides can be roughly divided into five major categories: acidic heteropolysaccharides, neutral heteropolysaccharides, cell wall polysaccharides, extracellular polysaccharides, and acid oligosaccharides. Its appearance is a white or off-white powder, easy to absorb moisture, soluble in water, prone to disperse in glycerin and propylene glycol, and insoluble in organic solvents such as ethanol and acetone.\u003c\/p\u003e\n\u003cp\u003eTremella polysaccharide can be regarded as a plant-derived hyaluronic acid substance with a molecular weight of up to 1.3-1.6 million Da, which is the only plant-derived moisturizer in the cosmetics raw materials industry with a molecular weight over 1 million Da so far. When compared with hyaluronic acid, it has better efficacies in many aspects such as high moisturizing efficiency, anti-oxidation, anti-aging, skin-touch improvement, thickening, and emulsification.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eEfficient Moisturizing\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eSnow Mushroom Polysaccharides \u003c\/span\u003ecan significantly enhance the hydratability of the skin cell, increase the moisture content of the skin, and form a layer of moisturizing protective film to reduce the moisture loss on the skin surface, with a dual effect of water retention and water holding.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eAntioxidation and Anti-Aging \u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eSnow Mushroom Polysaccharides \u003c\/span\u003ehas the certain capability to scavenge superoxide radicals and hydroxyl radicals and inhibit cell aging by inhibiting cell lipid peroxidation, so as to increase skin cell vitality to promote skin regeneration, delay skin aging as well as repair light-damaged skin.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eSkin Feeling Improvement\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSnow Mushroom Polysaccharides\u003cstrong\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eis a high molecular weight polymer with good skin affinity and viscosity. When added into skincare products for application, it can bring the skin a moisturized and fresh feeling without dryness and tension.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy Results\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eTremella fuciformis\u003c\/em\u003e polysaccharide (TFPS), which is the extract of \u003cem\u003eTremella fuciformis\u003c\/em\u003e Berk, has previously been demonstrated to exhibit potent anti-oxidative, anti-inflammatory, and anti-aging effects. A hydrogen peroxide-induced human skin fibroblast injury model was first established. MTT and reactive oxygen species (ROS) production assays, in addition to terminal deoxynucleotidyl transferase dUTP nick end labeling, reverse transcription-quantitative polymerase chain reaction, and western blotting was performed to investigate the protective effects of TFPS. Hydrogen peroxide decreased human skin fibroblast viability with a concurrent increase in ROS generation and cell apoptosis. Treatment with 0–400 µg\/ml TFPS alone for up to 48 h did not result in an alteration in cell viability. Notably, TFPS pre-treatment reduced oxidative stress and cell apoptosis in hydrogen peroxide-treated skin fibroblasts. In addition, there was profound inhibition of p16, p21, p53, and caspase-3 expression, and activation of the extracellular-signal-regulated kinase and Akt serine\/threonine kinase 1, following TFPS pre-treatment. Furthermore, it was revealed that TFPS additionally protected fibroblasts via the upregulation of SIRT1 expression, and this was abrogated by the SIRT1 inhibitor niacinamide. These results indicated that TFPS alleviated hydrogen peroxide-induced oxidative stress and apoptosis in skin fibroblasts via the upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative-stress-associated skin diseases and aging.[1]\u003c\/p\u003e\n\u003cp\u003eLPS induced inflammation and ROS production and promoted the secretion of cytokines such as TNF-\u003cem\u003eα\u003c\/em\u003e and IL-6. LPS also enhanced the nuclear translocation of NF\u003cem\u003eκ\u003c\/em\u003eB, which promoted inflammation by oxidative stress. However, pretreatment with TFPS profoundly inhibited the activation of Akt, p38MAPK, and NF\u003cem\u003eκ\u003c\/em\u003eB and attenuated the expression of MCP-1 in macrophages. Meanwhile, TFPS also decreased cytokine and ROS levels and attenuated cell inflammation after treatment with LPS. Moreover, miR-155, one of the key small RNAs which regulate NF\u003cem\u003eκ\u003c\/em\u003eB and inflammation in macrophages, was significantly downregulated. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSafety\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn our study, we tested the cytotoxicity of TFPS in RAW264.7 cells. Our data indicated that at concentrations between 0 and 300 \u003cem\u003eμ\u003c\/em\u003eg\/ml, there was no obvious cytotoxicity in RAW264.7 cells that were pretreated with TFPS, which suggested that the medicinal properties of TFPS were safe. Our data also indicates that the TNF-\u003cem\u003eα\u003c\/em\u003e and IL-6 expression levels in RAW264.7 cells decreased in a TFPS concentration-dependent manner. And the optimal TFPS anti-inflammatory concentration is 200 \u003cem\u003eμ\u003c\/em\u003eg\/ml. [3] \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eRecommended Use \u0026amp; Storage\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eINCI Nomenclature:\u003c\/strong\u003e\u003cem\u003e Tremella Fuciformis Polysaccharide\u003c\/em\u003e\u003cbr\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cspan\u003e778577-37-0\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water\u003cbr\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e White to off-white Powder\u003cbr\u003e\u003cstrong\u003eSuggested Use Levels:\u003c\/strong\u003e 0.1-0.5%\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e1.3-1.8 M Daltons\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e 93% Polysaccharides\u003cbr\u003e\u003cstrong\u003eDynamic viscosity(0.5%aq.sol.,25° C,2\/6rpm): \u003c\/strong\u003e1615 mPa·s\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eProtected from direct light and moisture at a temperature of 60°-70°F \u003cbr\u003e\u003cstrong\u003eShelf life:\u003c\/strong\u003e 24 months, properly stored, in a sealed container.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Uses:\u003c\/strong\u003e Snow Mushroom Extract Powder can act as a natural moisturizer to help improve the look and feel of dry, rough, or flaky skin. Further, this ingredient is suitable for nearly all skin types, as it can also help to reduce hyperpigmentation, which may help to even skin tone. Anti-Inflammatory Hydrating Pigment and Collagen Production. This material is \u003cspan\u003eespecially suitable for face masks, creams, emulsions, toners, and other cosmetics.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThis product should be added to a formulation at the recommended usage rate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHMW products should be added to the cool-down phase of the formulation.\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003e• HWM ingredients tend to gel when added to a liquid so mixing well while adding is recommended. Mix until the powdered extract completely dissolves. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product is cosmetic grade \u0026amp; for external use only.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eDocuments\u003c\/h5\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/SDS_-_Snow_Mushroom_Polysaccharides_4c45375e-d913-4771-88ef-a5e432209a0f.pdf?v=1741767760\" rel=\"noopener\" target=\"_blank\"\u003eSDS\u003c\/a\u003e   \u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_Snow_Mushroom_Polysaccharides_3ebf70e4-aeb0-48b8-a812-db6417df7c9b.pdf?v=1749707358\" target=\"_blank\" rel=\"noopener\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN250410\/BE\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_Snow_Mushroom_Polysaccharides_d59a6fe2-511d-4f80-8abe-0b3933fdb91e.pdf?v=1741765185\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN270226\/BE\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_Snow_Mushroom_Polysaccharides_261b5a5b-a64b-417d-bb8b-b05775d7694a.pdf?v=1741765591\" rel=\"noopener\" target=\"_blank\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN20240818\/BE\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca rel=\"noopener\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_Snow_Mushroom_Polysaccharides_1.pdf?v=1741766023\" target=\"_blank\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN260919\/BE\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca rel=\"noopener\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_Snow_Mushroom_Polysaccharides_f21ba5aa-37c6-4571-ab21-6ac247c525f8.pdf?v=1737082535\" target=\"_blank\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN20240818\/BE\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_SNOW_MUSHROOM_EXTRACT_POWDER_POLYSACCHARIDES_90_2484a31a-6186-4a92-86d2-586a68b5e68a.pdf?v=1741766413\" rel=\"noopener\" target=\"_blank\"\u003eCoA-\u003cspan class=\"OYPEnA text-decoration-none text-strikethrough-none\"\u003e\u003cspan class=\"OYPEnA text-decoration-none text-strikethrough-none\"\u003eLOT: BN260515\/BE\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cbr\u003e\u003ca rel=\"noopener\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0555\/5421\/2003\/files\/CoA_-_SNOW_MUSHROOM_EXTRACT_POWDER_POLYSACCHARIDES_90_1.pdf?v=1741766893\" target=\"_blank\"\u003eCoA-\u003cspan class=\"OYPEnA font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\"\u003eLOT: BN23101111\/BE\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Bulk Naturals","offers":[{"title":"5 Grams","offer_id":44691604308012,"sku":"3181684152982","price":18.12,"currency_code":"USD","in_stock":false},{"title":"10 Grams","offer_id":44691604340780,"sku":"3181684152999","price":29.45,"currency_code":"USD","in_stock":true},{"title":"25 Grams","offer_id":44691604373548,"sku":"3731814102525","price":65.7,"currency_code":"USD","in_stock":true},{"title":"50 Grams","offer_id":44691604406316,"sku":"3181684162042","price":118.95,"currency_code":"USD","in_stock":true},{"title":"100 Grams","offer_id":44691604439084,"sku":"3181684162066","price":208.0,"currency_code":"USD","in_stock":true},{"title":"250 Grams","offer_id":44691604471852,"sku":"3181684162097","price":445.0,"currency_code":"USD","in_stock":true},{"title":"500 Grams","offer_id":44691604504620,"sku":"3181684162110","price":799.0,"currency_code":"USD","in_stock":true},{"title":"1kg","offer_id":44691604537388,"sku":"sku-47524137894138","price":1450.0,"currency_code":"USD","in_stock":true},{"title":"25kg","offer_id":44691604570156,"sku":"sku-47524137926906","price":31500.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0618\/6260\/8940\/files\/snow-mushroom-tremella_a67d89dc-0fcb-4cdf-9201-cc447defd3be.jpg?v=1755794521","url":"https:\/\/littleredgeneralstore.com\/products\/snow-mushroom-polysaccharides-hyaluronic-acid-substitute-90","provider":"Little Red General Store","version":"1.0","type":"link"}